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pro·found [prəˈfaʊnd] ПРИЛ.
1. profound (extreme):
profound
profound
profound change
profound impression
profound effect, ignorance, interest
2. profound (strongly felt):
profound
profound
profound compassion, gratification, gratitude
profound respect, reverence, veneration, love
profound anger
profound distress
3. profound (intellectual):
profound
profound
profound remark
profound knowledge
profound truth, wisdom
PONS OpenDict

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Одноязычные примеры (не проверены редакцией PONS)
The advanced progression presents as profound motionlessness, catatonia, accompanied with tremors or rigidity.
en.wikipedia.org
Although withdrawal symptoms are often associated with the use of recreational drugs, many drugs have a profound effect on the user when stopped.
en.wikipedia.org
The effect on the soul of the nation was profound.
en.wikipedia.org
This song helped the band become recognized as a mature band that could do more profound songs.
en.wikipedia.org
This substantial reduction in friction can have a profound effect on the system.
en.wikipedia.org